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INDIANAPOLIS — Authorities on Tuesday night closed two major roads — I-70 eastbound and Pendleton Pike — after serious crashes in Marion County, leaving two men driving vehicles dead.

Both roads had reopened to traffic by 10:30 p.m.

On the city’s far east side, I-70 eastbound east of Post Road was closed after the fatal crash involving a van, a car and two semitractor-trailers.

Rita Reith, a battalion chief and spokeswoman for Indianapolis Fire Department, said said crews were sent about 5:15 p.m. to the 92.6-mile marker on I-70 near German Church Road. A witness said a semi did not stop to avoid stopped traffic. The semi hit the back of a van and pushed it into a sedan, which collided with another semi.

Indiana State Police said the semi was not exceeding the posted speed limit prior to the crash, and alcohol is not believed to be a factor in the crash.

The driver of the van, a man in his 60s, received CPR from bystanders — Tresa Quick, 47, of Indianapolis and Andre Davis, 27, of Greenfield — before medical crews arrived. The man later died at Sidney & Lois Eskenazi Hospital, Reith said in an email. His identity is not being released until his family is notified.

The two men in their 40s in the sedan also were taken to Eskenazi hospital, where they were in good condition.

Two dogs ejected from the van also died in the crash, Reith said.