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INDIANAPOLIS — The Indianapolis Colts will open the 2021 NFL season at home against the Seattle Seahawks.
The home opener will be at Lucas Oil Stadium on Sunday, Sept. 12 at 1 p.m.
Single-game tickets to Week 1 and all the team’s 2021 home games go on sale beginning Thursday, May 13 at 11 a.m. ET at or via Ticketmaster.
The Colts will host Seattle for the first time since 2013. Indianapolis leads the overall regular-season series 7-5, including 3-1 at home. In Week 4 of the 2017 season, the Seahawks hosted and defeated the Colts, 46-18.
The rest of the Colts’ 2021 schedule will be released tonight at 7:45 p.m. ET.